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Metformin
Your health and safety comes first. Discover essential information about your medication, possible side effects, and important safety guidance related to your treatment.
Metformin XR is a medication approved by the U.S. Food and Drug Administration (FDA) to support better blood sugar regulation in adults with type 2 diabetes, alongside a healthy diet and regular exercise. Healthcare professionals may also recommend it for other medically appropriate purposes.
Prescribing information
Important safety information
Metformin XR is a prescription drug approved for individuals with type 2 diabetes who cannot manage high blood sugar levels through diet and exercise alone.
Some healthcare providers may prescribe Metformin XR “off-label” to help individuals with excess weight or obesity reduce and maintain weight loss over time.
Key Safety Considerations
In rare cases, this medication can lead to a serious condition known as lactic acidosis, where lactic acid accumulates in the bloodstream. This can be life-threatening and requires emergency treatment in a hospital.
Seek immediate medical attention and stop using Metformin XR if you experience any of the following:
-
Unusual fatigue or weakness
-
Muscle pain unrelated to exercise
-
Breathing difficulties
-
Excessive drowsiness
-
Nausea, vomiting, or diarrhea with no clear cause
-
Feeling cold in the limbs
-
Dizziness or lightheadedness
-
Slowed or irregular heart rate
Factors that increase risk for lactic acidosis:
-
Impaired kidney or liver function
-
Heart failure requiring treatment
-
Frequent or heavy alcohol use
-
Severe dehydration (e.g., from fever, vomiting, or sweating without fluid intake)
-
Certain imaging tests using contrast dyes
-
Major surgery
-
Serious infections, heart attack, or stroke
-
Age 80+ without recent kidney assessment
Common Side Effects
• Abdominal distress
• Nausea
• Diarrhea
• Vomiting
Avoid Using Metformin XR If You:
-
Have known kidney disease or impaired kidney function
-
Have elevated creatinine levels (not exceeding daily dose of 500mg)
-
Are allergic to metformin or any inactive components in the tablet
-
Are undergoing procedures involving contrast dye or surgery requiring fasting
-
Have type 1 diabetes or are at risk for diabetic ketoacidosis
-
Have kidney, liver, or heart conditions
-
Are over 80 years old without a recent kidney function test
-
Drink alcohol frequently or in large amounts
-
Are taking insulin
-
Are currently pregnant, planning pregnancy, or breastfeeding
-
Are taking other prescription or over-the-counter medications, herbal supplements, or vitamins
Keep a list of all your current medications to review with your provider or pharmacist to avoid interactions.
Typical Side Effects
Some people may experience digestive upset (nausea, diarrhea, stomach discomfort) when starting Metformin XR. These symptoms often subside over time and may be minimized by taking the medication with food.
A small percentage (approximately 3%) of users may notice a metallic taste, which is usually temporary.
Hypoglycemia (low blood sugar) is not typically caused by Metformin XR alone but can occur if you skip meals, consume alcohol, or use other glucose-lowering medications concurrently.
Need to Report a Side Effect?
You can notify the FDA of any adverse reactions by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.
Disclaimer:
This content is intended for informational purposes and should not replace personalized guidance from a licensed healthcare provider. Any medical decisions should be made in partnership with a professional familiar with your individual health history. This information is intended for U.S. residents only, and product details may differ internationally.
Critical Warnings About Metformin XR
Speak With Your Provider Before Starting If You:
Speak With Your Provider Before Starting If You:
-
Have type 1 diabetes or are at risk for diabetic ketoacidosis
-
Have kidney, liver, or heart conditions
-
Are over 80 years old without a recent kidney function test
-
Drink alcohol frequently or in large amounts
-
Are taking insulin
-
Are currently pregnant, planning pregnancy, or breastfeeding
-
Are taking other prescription or over-the-counter medications, herbal supplements, or vitamins
Keep a list of all your current medications to review with your provider or pharmacist to avoid interactions.
Typical Side Effects
Some people may experience digestive upset (nausea, diarrhea, stomach discomfort) when starting Metformin XR. These symptoms often subside over time and may be minimized by taking the medication with food.
A small percentage (approximately 3%) of users may notice a metallic taste, which is usually temporary.
Hypoglycemia (low blood sugar) is not typically caused by Metformin XR alone but can occur if you skip meals, consume alcohol, or use other glucose-lowering medications concurrently.
Need to Report a Side Effect?
You can notify the FDA of any adverse reactions by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.
Disclaimer:
This content is intended for informational purposes and should not replace personalized guidance from a licensed healthcare provider. Any medical decisions should be made in partnership with a professional familiar with your individual health history. This information is intended for U.S. residents only, and product details may differ internationally.
Critical Warnings About Metformin XR
Metformin XR is a prescription drug approved for individuals with type 2 diabetes who cannot manage high blood sugar levels through diet and exercise alone.
Some healthcare providers may prescribe Metformin XR “off-label” to help individuals with excess weight or obesity reduce and maintain weight loss over time.
In rare cases, this medication can lead to a serious condition known as lactic acidosis, where lactic acid accumulates in the bloodstream. This can be life-threatening and requires emergency treatment in a hospital.
Seek immediate medical attention and stop using Metformin XR if you experience any of the following:
-
Unusual fatigue or weakness
-
Muscle pain unrelated to exercise
-
Breathing difficulties
-
Excessive drowsiness
-
Nausea, vomiting, or diarrhea with no clear cause
-
Feeling cold in the limbs
-
Dizziness or lightheadedness
-
Slowed or irregular heart rate
Factors that increase risk for lactic acidosis:
-
Impaired kidney or liver function
-
Heart failure requiring treatment
-
Frequent or heavy alcohol use
-
Severe dehydration (e.g., from fever, vomiting, or sweating without fluid intake)
-
Certain imaging tests using contrast dyes
-
Major surgery
-
Serious infections, heart attack, or stroke
-
Age 80+ without recent kidney assessment