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Weight Loss by EONMeds. See if you qualify now!

Weight Loss by EONMeds. See if you qualify now!

NAD+

Your wellness starts at the cellular level. Explore important facts about this treatment, including how it works, potential side effects, and what to know before starting.

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NAD+ is a coenzyme found in every living cell and plays a key role in converting nutrients into energy. It also supports DNA repair and helps regulate cellular aging. Healthcare professionals may use NAD+ therapies to support energy, cognitive function, metabolism, and recovery.

Prescribing information

  • No black box warnings currently apply

  • Dosage varies based on treatment goal and delivery method (oral, sublingual, injection, or IV)

Critical Warnings About Metformin XR
Common Side Effects

• Flushing or warmth at the injection site

• Nausea  
• Mild Fatigue
• Headache

Key Safety Considerations

Metformin XR is a prescription drug approved for individuals with type 2 diabetes who cannot manage high blood sugar levels through diet and exercise alone.

 

Some healthcare providers may prescribe Metformin XR “off-label” to help individuals with excess weight or obesity reduce and maintain weight loss over time.

While generally well tolerated, NAD+ can occasionally cause side effects—especially when administered intravenously or in high doses.

 

Stop treatment and seek medical attention if you experience any of the following symptoms:

 

  • Chest tightness

  • Shortness of breath

  • Sudden drop in blood pressure

  • Severe flushing or heart palpitations

  • Swelling of the face or throat (allergic reaction)

 

People Who Should Use Caution or Avoid NAD+ Therapy Include Those Who:

 

  • Are pregnant or breastfeeding (safety not established)

  • Have active cancer (NAD+ may stimulate cell repair mechanisms)

  • Have known sensitivity or allergy to NAD+ formulations

  • Are taking immunosuppressants or undergoing chemotherapy (consult a provider)

NAD+ therapy is not FDA-approved to treat or cure any disease but may be prescribed or recommended off-label for wellness support, including fatigue, aging-related decline, and brain fog. It may also be used as part of anti-aging and metabolic health programs.

 

When used under medical supervision, NAD+ supplementation may help enhance mitochondrial function, increase focus and alertness, and support overall cellular repair.

Important safety information

In rare cases, this medication can lead to a serious condition known as lactic acidosis, where lactic acid accumulates in the bloodstream. This can be life-threatening and requires emergency treatment in a hospital.

 

Seek immediate medical attention and stop using Metformin XR if you experience any of the following:

 

  • Unusual fatigue or weakness

  • Muscle pain unrelated to exercise

  • Breathing difficulties

  • Excessive drowsiness

  • Nausea, vomiting, or diarrhea with no clear cause

  • Feeling cold in the limbs

  • Dizziness or lightheadedness

  • Slowed or irregular heart rate

 

Factors that increase risk for lactic acidosis:

 

  • Impaired kidney or liver function

  • Heart failure requiring treatment

  • Frequent or heavy alcohol use

  • Severe dehydration (e.g., from fever, vomiting, or sweating without fluid intake)

  • Certain imaging tests using contrast dyes

  • Major surgery

  • Serious infections, heart attack, or stroke

  • Age 80+ without recent kidney assessment

Critical Warnings About NAD+
Avoid Using Metformin XR If You:

  • Are pregnant or breastfeeding (safety not established)

  • Have active cancer (NAD+ may stimulate cell repair mechanisms)

  • Have known sensitivity or allergy to NAD+ formulations

  • Are taking immunosuppressants or undergoing chemotherapy (consult a provider)

  • Have type 1 diabetes or are at risk for diabetic ketoacidosis

  • Have kidney, liver, or heart conditions

  • Are over 80 years old without a recent kidney function test

  • Drink alcohol frequently or in large amounts

  • Are taking insulin

  • Are currently pregnant, planning pregnancy, or breastfeeding

  • Are taking other prescription or over-the-counter medications, herbal supplements, or vitamins

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Keep a list of all your current medications to review with your provider or pharmacist to avoid interactions.

 

Typical Side Effects

Some people may experience digestive upset (nausea, diarrhea, stomach discomfort) when starting Metformin XR. These symptoms often subside over time and may be minimized by taking the medication with food.

 

A small percentage (approximately 3%) of users may notice a metallic taste, which is usually temporary.

 

Hypoglycemia (low blood sugar) is not typically caused by Metformin XR alone but can occur if you skip meals, consume alcohol, or use other glucose-lowering medications concurrently.

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Need to Report a Side Effect?

You can notify the FDA of any adverse reactions by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

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Disclaimer:

This content is intended for informational purposes and should not replace personalized guidance from a licensed healthcare provider. Any medical decisions should be made in partnership with a professional familiar with your individual health history. This information is intended for U.S. residents only, and product details may differ internationally.

Speak With Your Provider Before Starting If You:
Speak With Your Provider Before Starting If You:

  • Have any chronic medical conditions (especially heart, kidney, or liver issues)

  • Are undergoing treatment for any serious illness

  • Are taking other supplements or medications

  • Are seeking treatment for addiction or withdrawal (may require special dosing)

  • Have low blood pressure or are prone to dizziness

 

Typical Side Effects

Some users report temporary side effects, especially with higher-dose IV infusions or intramuscular injections. These may include nausea, fatigue, or mild discomfort at the site of injection. Slowing the infusion rate may improve tolerance.

 

NAD+ does not typically cause dependency, sedation, or low blood sugar. Most individuals feel energized or mentally clearer shortly after treatment.

 

Need to Report a Side Effect?

If you experience any unexpected reactions to NAD+ therapy, you can report it to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

 

Disclaimer:

This information is intended for educational purposes only and does not replace medical advice from a licensed healthcare provider. All treatment decisions should be made with your healthcare team. NAD+ therapies are not intended to diagnose, treat, or cure any condition. Availability and labeling may differ by country.

tnership with a professional familiar with your individual health history. This information is intended for U.S. residents only, and product details may differ internationally.

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